Technology : Engineered Drug Therapies™
A Unique First Opportunity for Liquidia
Developing innovative solutions for drug delivery and improved therapeutics is at the core of Liquidia's mission. The ability to independently control particle size, shape, modulus, surface functionality enables Liquidia to design novel carriers for drug delivery and develop targeted therapeutic products for oncology and several other indications.
Cellular uptake of PRINT™ particles
Liquidia's initial development efforts are focused on delivery of nucleic acids and targeted oncology therapeutics. Additionally, Liquidia is using the unique properties of PRINT™ particles to develop new approaches for inhaled and ocular therapeutics. Click here to view the Liquidia pipeline. The unique ability of Liquidia's PRINT platform to control nanoparticle size, morphology, and monodispersity offers a unique solution that will enable Liquidia and its partners to develop therapeutics with improved safety, efficacy, and/or dosing requirements.
| PRINT™ Technology Features |
- Discrete, non-disperse, molded particles (10s of nm - 100s of µm in size)
- Wide range of particle size and shape profiles
- Ability to select from a large variety of matrix compositions (e.g. organic polymers, organic and inorganic materials, active pharmaceutical ingredients and biologics)
- Able to carry a large therapeutic payload
- Tailored surface and matrix properties (e.g. targeting ligands, surface charge)
- Particle modulus/flexibility control
- Triggered release mechanisms - designed to respond to biological and environmental changes (e.g. pH, temperature, and presence of specific enzymes
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| Delivery and Therapeutic Benefits |
- Cell and site-specific targeting:
- Drug particles concentrate at the intended site of action
- Minimal systemic exposure
- Reduced off-target effects
- Cellular uptake & intracellular release
- Long or short circulation time
- Improved therapeutic efficacy and reduced dosing requirements
- Improved solubility
- Enhanced API dissolution rate
- Improved ability to cross biological barriers (e.g. blood brain barrier, cell membranes, extracelluear matrices)
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