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Liquidia utilizes a proprietary PRINT Technology platform.
Product Platform

Inhaled Therapeutics
Other Programs
Publications :

Morton, S. W., Herlihy, K. P., Shopsowitz, K. E., Deng, Z. J., Chu, K. S., Bowerman, C. J., DeSimone, J. M. and Hammond, P. T. (2013), Scalable Manufacture of Built-to-Order Nanomedicine: Spray-Assisted Layer-by-Layer Functionalization of PRINT Nanoparticles. Adv. Mater.. doi: 10.1002/adma.201302025

Maynor, B.; Garcia, A.; Tully, J.; Yerxa, B. "Application of PRINT Microparticle and Nanoparticle Technology – Toward Preparation of Ophthalmic Suspension Formulations with Improved Tolerability and Efficacy". ARVO abstract and poster presentation, Drug Delivery I session, May 2013.

Garcia, A.; Tully, J.; Maynor, B.; Yerxa, B. "Precisely Engineered Biodegradable Intraocular Implants for the Sustained Release of Dexamethasone". ARVO abstract and poster presentation, Drug Delivery I session, May 2013.

“Development of a Nanoparticle-BasedIinfluenza Vaccine using the PRINT® Technology"; Galloway, A. L.; Murphy, A.; DeSimone, J. M.; Di, J.; Herrmann, J. P.; Hunter, M. E.; Kindig, J. P.; Malinoski, F. J.; Rumley, M. A.; Stoltz, D. M.; Templeman, T. S.; & Hubby, B. Nanomedicine: Nanotechnology, Biology and Medicine, May 2013, 9(4), pp. 523–531.

"Particle Engineering for Inhalation Formulation and Delivery of Biotherapeutics"; Mack, P.; Horvath, K.; Garcia, A.; Tully, J.; and Maynor, B. Inhalation. August 2012.

“PEGylated PRINT Nanoparticles: The Impact of PEG Density on Protein Binding, Macrophage Association, Biodistribution, and Pharmacokinetics”; Perry, J. L.#; Reuter, K. G.#; Kai, M. P.; Herlihy, K. P.; Jones, S. W.; Luft, J. C.; Napier, M. E.; Bear, J. E.; DeSimone, J. M.; Nanoletters, 2012, 12, 5304.

"Rendering Protein-based Particles Transiently Insoluble for Therapeutic Applications"; Xu, J.; Wang, J.; Luft, J. C.; Tian, S.; Owens, G.; Pandya, A.; Berglund, P.; Pohlhaus, P. D.; Maynor, B. W.; Napier, M. E.; DeSimone, J. M. J. Am. Chem. Soc. 2012, DOI: 10.1021/ja302363r.

"Reductively-Responsive siRNA-Conjugated Hydrogel Nanoparticles for Gene Silencing"; Dunn, S. S.; Tian, S.; Blake, S.; Wang, J.; Galloway, A. L.; Murphy, A.; Pohlhaus, P. D.; Rolland, J. P.; Napier, M. E.; and DeSimone, J. M. J. Am. Chem. Soc., Just Accepted Manuscript • DOI: 10.1021/ja300174v • Publication Date (Web): 05 Apr 2012.

"Delivery of Multiple siRNAs Using Lipid-coated PLGA Nanoparticles for treatment of Prostate Cancer"; Hasan, W.; Chu, K.; Gullapalli, A.; Dunn, S. S.; Enlow, E.; Luft, J. C.; Tian, S.; Napier, M.E.; Pohlhaus, P. D.; Rolland, J. P.; DeSimone*, J. M. NanoLetters 2012, 12, 287-292.

"Microfabricated Engineered Particle Systems for Respiratory Drug_Delivery and Other Pharmaceutical Applications" ;Garcia, A.; Mack, P.; Williams, S.; Fromen, C.; Shen, T.; Tully, J.; Pillai, J.; Kuehl, P.; Napier, M. E.; DeSimone, J. M.; and Maynor, B. Journal of Drug Delivery. 2012

"Engineering Nanomedicines Using Stimuli-responsive Biomaterials"; Wang, Y.; Byrne, J. D.; Napier, M. E.; DeSimone*, J. M. Advanced Drug Delivery Reviews 2011, in press.

"Microfabricated, Engineered Particles for Efficient Inhalation Drug Delivery"; Maynor, B. W.; Presented at Drug Delivery to the Lungs 22, December 2011.

"PRINT: A Novel Platform Toward Shape and Size Specific Nanoparticle Theranostics"; Perry, J. L.; Herlihy, K. P.; Napier, M. E.; DeSimone*, J. M. Accounts of Chemical Research 2011, 44(10), 990-998.

"Engineering More Effective Nanomedicines Through Particle Design"; Wang, J.; Byrne, J. D.; Napier, M. E.; DeSimone*, J. M. Small 2011, 7(14), 1919-1931.

Ashley L. Galloway, Andrew Murphy, Jason P. Rolland, Kevin P. Herlihy, Robby A. Petros, Mary E. Napier, and Joseph M. DeSimone; "Micromolding for the Fabrication of Biological Microarrays" in Biological Microarrays: Methods and Protocols; Eds A. Khademhosseini; K.-Y Suh; M. Zourob; 2011; pp. 249-260.

"Novel Platforms for Vascular Carriers with Controlled Geometry"; Pillai, J.; Dunn, S. S.; Napier, M. E.; DeSimone*, J. M. International Union of Biochemistry and Molecular Biology: Life 2011, 63(8), 596-606.

Control of Nano- and Micro-Particle Size, Shape, Dispersity and Elasticity: Development of Vaccine and Therapeutic Particles for Use in Parenteral and Inhalation Routes of Administration. Presented at SMART Drug Delivery Workshop , Washington, DC.DeSimone, J.M.; Mack, P.D. (2011, August).

PRINT® Particles and Well Arrays for Next Generation Sequencing; Knutson, T.; Maynor, B.; Nijhawan, A. 2011

"Using mechanobiological mimicry of red blood cells to extend circulation times of hydrogel microparticles"; Merkel, T. J.; Jones, S. W.; Herlihy, K. P.; Kersey, F. R.; Shields, A. R.; Napier, M.; Luft, J. C.; Wu, H.; Zamboni, W. C.; Wang, A. Z.; Bear, J. E.; and DeSimone, J. M., Proceedings of National Academy of Sciences 2011, 108(2) 586-591.

"Potent Engineered PLGA Nanoparticles by Virtue of Exceptionally High Chemotherapeutic Loadings"; Enlow, E.M.; Luft, J.C.; Napier, M.E.; DeSimone, J.M., Nano Letters 2011, (DOI: 10.1021/nl104117p).

"Tunable Bi-functional Silyl Ether Cross-Linkers for the Design of Acid Sensitive Biomaterials"; Parrott, M. C.; Luft, J. C.; Byrne, J. D.; Fain, J. H.; Napier, M. E.; DeSimone*, J. M. J. Am. Chem. Soc. 2010, 132(50), 17928-17932.

"Microfabricated, Shape-Specific Particles and Engineered Aerosols for Efficient Aerosol Delivery to the Lung";Maynor B.W.; Garcia, A.; Duong, H.; Mack, P. Respiratory Drug Delivery 2010 , 2010 Vol 2, pp 619-622

PRINT® Technology: Enabling Next Generation Sequencing; Knutson, T.; Maynor, B.; Zhou, Z.; Chenet, K. 2010.

Nanomanufacturing: The Missing Link between Discovery and Products [White Paper]. Rothrock, G., Pishny,E., & DeSimone, J. 2009.

"The Complex Role of Multivalency in Nanoparticles Targeting the Transferrin Receptor for Cancer Therapies"; Wang, J.; Tian, S.; Petros, R. A.; Napier, M. E.; DeSimone*, J. M. J. Am. Chem. Soc. 2010, 132 (32), pp 11306–11313 (DOI: 10.1021/ja1043177)

"Top-down Particle Fabrication: Control of Size and Shape for Diagnostic Imaging and Drug Delivery"; Canelas, D. A.; Herlihy, K. P.; DeSimone*, J. M. Advanced Reviews Wiley 2009, 1 (4), 391-404.

"The Effect of Particle Design on Cellular Internalization Pathways"; Gratton, S. E. A.; Ropp, P. A.; Pohlhaus, P. D.; Luft, J. C.; Madden, V. J.; Napier, M. E.; DeSimone*, J. M. Proceedings of the National Academy of Sciences 2008, 105(33), 11613-11618.

"Shape-specific, Mono-disperse Nano-molding of Protein Particles"; Kelly, J. Y.; DeSimone*, J. M. J. Am. Chem. Soc. 2008, 130, 5438-5439.

"Microfabricated Particles for Engineered Drug Therapies: Elucidation into the Mechanisms of Cellular Internalization of PRINT Particles"; Gratton, S. E. A.; Napier, M. E.; Ropp, P. A.; Tian, S. DeSimone*, J. M. Pharm. Res. 2008, 25, 2845-2852.

"Reductively Labile PRINT Nanoparticles for the Delivery of Doxorubicin to HeLa Cells"; Petros, R. A.; Ropp, P. A.; DeSimone*, J. M.; J. Am. Chem. Soc. 2008, 130, 5008-5009.

"The Pursuit of a Scalable Nano-fabrication Platform for Use in Material and Life Science Applications"; Gratton, S. E. A.; Williams, S. S.; Napier, M. E.; Pohlhaus, P. D.; Zhou, Z.; Wiles, K. B.; Maynor, B. B.; Shen, C.; Olafsen, T.; Samulski, E. T.; DeSimone*, J. M. Accounts of Chemical Research 2008, 41, 1685-1695.

"Nanoparticle Drug Delivery Platform"; Napier, M. E.; DeSimone*; J. M. Polymer Reviews 2007, 47, 321-327

"Nanofabricated Particles for Engineered Drug Therapies: A Preliminary Biodistribution Study of PRINTTM Nanoparticles"; Gratton, S. E. A.; Pohlhaus, P. D.; Lee, J.; Guo, J.; Cho, M. J.; DeSimone*, J. M. J. Controlled Release 2007, 121, 10-18.

"Imparting Size, Shape, and Composition Control of Materials for Nanomedicine"; Eulis, L.; DuPont, J.; DeSimone*, J. M. Chem. Soc. Rev. 2006, 35, 1095-1104.

"Direct Fabrication and Harvesting of Monodisperse, Shape Specific Nano-Biomaterials"; Rolland, J. P.; Maynor, B. W.; Euliss, L. E.; Exner, A. E.; Denison, G. M.; DeSimone*, J. M J. Am. Chem. Soc. 2005, 127, 10096-10100.

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